25 October 2004
Induction of pro-inflammatory cytokine gene expression and apoptosis in human chorion cells of fetal membranes by influenza virus infection: possible implications for maintenance and interruption of pregnancy during infection
Noboru Uchide, Kunio Ohyama, Toshio Bessho, Hiroo ToyodaMed Sci Monit 2005; 11(1): RA7-16 :: ID: 13886
Abstract
Human fetal membranes are composed of amnion, chorion and decidua tissues, which play a critical role in defense barriers as well as maintenance of pregnancy and parturition. Pro-infl ammatory cytokines, such as interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α, produced by the tissues are postulated to facilitate parturition. Infl uenza virus infection is one of causes of pregnancy-
associated complications, such as premature delivery, abortion and stillbirth. Recent studies have demonstrated that infl uenza virus infection induced the gene expression of a set of pro-infl ammatory
cytokines, such as IL-1β, IL-6, TNF-α, interferon (IFN)-β, IFN-g and granulocyte macrophage colony-stimulating factor (GM-CSF), and the secretion of unidentifi ed monocyte differentiationinducing factor(s) from primary cultured chorion cells undergoing apoptosis. These phenomena were not observed in primary cultured amnion cells infected with the virus. This article reviews,1) the production of cytokines in fetal membrane tissues and their functions; 2) the differential induction of pro-infl ammatory cytokine gene expression and apoptosis in fetal membrane chorion and amnion cells by infl uenza virus infection. An accumulating number of evidence suggests that interactive reactions between fetal membrane chorion cells and maternal monocytes/macrophages may play a critical role in defense barriers against the virus infection. Understanding the interactions would make important contributions to the elucidation of the pathogenesis of infl uenza virus infection during pregnancy.
Keywords: Amnion - immunology, Amnion - virology, Chorion - immunology, Chorion - virology, Decidua - virology, Extraembryonic Membranes - immunology, Extraembryonic Membranes - virology, Influenza, Human - complications, Influenza, Human - immunology, Pregnancy Complications, Infectious - metabolism, Amnion - virology, Chorion - virology, Cytokines - genetics, Decidua - virology, Extraembryonic Membranes - virology, Influenza, Human - immunology, Pregnancy, Pregnancy Complications, Infectious - metabolism
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952