Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

20 May 2003 : Original article  

Living related donor liver transplantation from Hepatitis B core antibody positive donor

I. Jankowska, J. Pawłowska, P. Kaliciński, M. Teisseyre, A. Kamiński, J. Kuszyk, P. Kluge, M. Pronicki, J. Socha

Med Sci Monit 2003; 9(2): 20-0 :: ID: 15303

Abstract

Background: Transmissions of hepatitis B virus (HBV)infection from donors negative for hepatitis B surface antigen (HBsAg)but positive for antibody to hepatitis B core antigen (anti-HBc) have been reported.The recipient risk to develop hepatitis B from an anti-HBc positive donors has been estimated to be up to 78%but in emergency cases the decision to perform trans- plantation should be considered. The aim of the study was to analyse the outcome of living related anti-HBc positive donor liver transplantation in children. Material/Methods:3 out of 88 children with living related liver transplantation received a liver from an anti-HBc positive donor.All children had liver cirrhosis due to biliary atresia. Transplantation was done at the age of 12.21 and 22 months, in life-threatening situations,after 6 month waiting time for cadaveric liver transplantation.Recipients were HBsAg and anti-HBc negative.All children were vaccinated before transplantation with anti-HBs title above 1000 mIU/ml on the day of transplantation.In all living related donors HBsAg and anti-HBc antibody were determined before transplantation. Three anti-HBc positive donors were tested for HBV DNA in serum and liver by PCR method. Results:Serum of all anti-HBc positive donors was negative for HBV DNA. Liver biopsies showed no inflammation but in two cases liver tissue was positive for HBV-DNA by PCR test.All three recipients are followed up for 10 –24 months after liver transplantation.None of them developed HBV infection. Conclusions: 1.In case of life threatening situations anti-HBc positive donors can be accepted for living related liver transplantation.2.It is important to vaccinate and verify the antibody response to the vaccination before and after transplantation.

Keywords: Hepatitis B

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750