22 February 2002
Evaluation of lymphocyte subsets and NK cells in septic children.
M Banasik, Jiri Zeman, Teresa Woźniakowska-GesickaMed Sci Monit 2002; 8(2): CR119-124 :: ID: 420929
Abstract
BACKGROUND: Disorders of lymphocyte subpopulations counts and NK cellsmay not only contribute to impaired elimination of pathogens, but also be an important factor in thedevelopment of generalized inflammatory reaction. The aim of the paper was the analysis of subpopulationsof lymphocytes and NK cells in children with sepsis and after recovery. MATERIAL/METHODS: The study comprised25 septic children (17 infants and 8 children aged from 1 to 3 years). The control group consisted of25 healthy children. The study was conducted in the initial phase of sepsis and then repeated 2 to 3months after recovery. In all the children, the percentage and absolute numbers of basic lymphocyte subsetsand NK cells in blood serum were evaluated. RESULTS: In the course of sepsis, the absolute number ofactivated lymphocytes T in the youngest children was higher in comparison with the control group. Afterrecovery, the percentage and absolute counts of CD4 lymphocytes in all the children and CD3/CD4 lymphocytesratio in the youngest children were considerably lower than in the control group. The percentage andabsolute number of NK cells in the youngest children after recovery were higher in comparison with thecontrol group. CONCLUSIONS: In children who underwent sepsis, depression traits of cellular immunityare observed. The occurrence of defensive system disorders after recovery may be an important factorin recurrent infections and creates the necessity of immune system monitoring in children with the historyof sepsis for the purpose of prevention.
Keywords: Case-Control Studies, Child, Preschool, Lymphocyte Subsets, Sepsis
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952