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eISSN: 1643-3750

Application of ursodeoxycholic acid (UDCA) in the therapy of liver and biliary duct diseases in children

Dariusz Marek Lebensztejn

Med Sci Monit 2000; 6(3): RA632-636

ID: 421296


The paper discusses the experience accumulated so far in the field of applicationof ursodeoxycholic acid (UDCA) in selected disorders of the liver and biliary ducts in the developmentalage population. In the aforementioned diseases, chronic administration of UDCA is safe, reduces the clinicalsymptoms, improves the biochemical parameters, and even the histopathologic picture of the affected organ.Such a therapy should be instituted in order to improve the quality of life, reduce the incidence ofcomplications and postpone the transplantation of the liver till the time the child is older.

Keywords: Alagille Syndrome, Bile Duct Diseases, Child, Cholagogues and Choleretics, Cholestasis, Intrahepatic, Cystic Fibrosis, Humans, Liver Diseases, Parenteral Nutrition, Total, ursodeoxycholic acid