Evaluation of selected cytokines and mononuclear cell infiltration in gastricmucosa of children with food allergy.
Janusz Dzięcioł, Elżbieta Maciorowska, Andrzej Kemona, Maciej Kaczmarski
Med Sci Monit 2000; 6(3): CR567-572
The authors performed simultaneous evaluation of histological changes ingastric and duodenal mucosa, phenotypic evaluation of mononuclear cells infiltration and the levels ofselected cytokines of gastric mucosa in children with diagnosed food allergy. It was determined thatIL-4, IL-5, IL-10 and TNF-alpha were produced locally within alimentary tract mucosa; they may play pathogenicrole in food hypersensitivity in children. Increase in the number of T lymphocytes (CD3+, CD8+) and Blymphocytes (CD20+) as well as mastocytes with positive reaction to Mast Cell Tryptase-Mastocyte antibodywas also observed in gastric and duodenal mucosa of these patients.
Keywords: Adolescent, Antigens, CD, B-Lymphocytes, Child, Child, Preschool, Cytokines, Duodenum, Female, Food Hypersensitivity, Gastric Mucosa, Humans, Inflammation Mediators, Interleukin-10, Interleukin-4, Interleukin-5, Intestinal Mucosa, Male, Research Support, Non-U.S. Gov, Serine Endopeptidases, T-Lymphocytes, Tumor Necrosis Factor-alpha