eISSN: 1643-3750


House dust-mites: Effect on antioxidant enzyme activities

Aysun Bay Karabulut, Metin Atambay, Ulku Karaman, Eser Kilic, Suleyman Yazar, Recep Saraymen, Nilgun Daldal

Med Sci Monit 2006; 12(9): CR378-381

ID: 455249

Published: 2006-09-01

Background:House dust-mites are potent allergens of the indoor environment and are common inhabitants of houses worldwide. Free radicals are constantly produced by cells, mostly as reactive oxygen species. Once produced, free radicals are removed by antioxidant defenses, including the enzymes SOD, GPx, and CAT.
Material/Methods:    The aim was to describe the importance of the antioxidant enzymes SOD, GPx, and CAT co-acting in human cells against toxic reactive oxygen species and their relationship with pathophysiological processes in subjects who have dust-mites in their homes.
Results:    The activities of erythrocyte GPx and SOD in skin-test-positive (dust-mite-positive/negative) patients were significantly lower than those in dust-mite- and skin-test-negative controls (p

Keywords: Aged, Adult, Adolescent, Animals, Catalase - blood, Child, Down-Regulation, Erythrocytes - enzymology, Female, Glutathione Peroxidase - blood, Humans, Intradermal Tests, Male, Middle Aged, Pyroglyphidae - immunology, Superoxide Dismutase - blood