Serum neopterin concentrations in healthy healthcare workers compared with healthy controls and patients with pulmonary tuberculosis
Davut Ozdemir, Salih Cesur, Ali Nihat Annakkaya, Gulnur Tarhan, Nevin Taci Hoca, Irfan Sencan, Turan Aslan, Ismail Ceyhan, Oner Balbay, Ertugrul Guclu
Med Sci Monit 2006; 12(12): CR521-524
Background: The aim of this study was to compare serum neopterin levels in patients with active pulmonary tuberculosis, healthy healthcare workers who had close contact with patients, and healthy volunteers. All of the healthy volunteers stated that they had not encountered possible risk factors for exposure to Mycobacterium tuberculosis infection.
Material/Methods: Thirty-nine patients, 39 healthy healthcare workers, and a control group of 39 healthy volunteers who had no infection or other diseases were included in this study. Neopterin assay was performed in accordance with the manufacturer’s instructions.
Results: Serum neopterin levels were 18.6±14.2 nmol/l in patients, 9.8±2.9 nmol/l in healthy healthcare workers, and 3.4±5.2 nmol/l in healthy volunteers. Serum neopterin levels in each group were signifi cantly different from each other (p
Keywords: Aged, Tuberculosis, Pulmonary - etiology, Risk Factors, Neopterin - blood, Middle Aged, Male, Humans, Health Personnel, Female, Case-Control Studies, Carrier State - diagnosis, Adult, Turkey