Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 May 1996

Sex hormone levels after the glucose load in women with polycystic ovary syndrome

Artur Jakimiuk, Krzysztof Postawski, Lechosław Putowski, Jerzy A. Jakowicki

Med Sci Monit 1996; 2(3): CR287-291 :: ID: 499797

Abstract

The aim of the study was to look at the response of blood androgens, sex hormone-binding globulin (SHBG) and insulin to the oral glucose tolerance test (OGTT) in women with polycystic ovary syndrome (PCOS). Eight hirsute oligomenorrhoeic women with PCOS, body mass index (BMI) 24.8±4.9 kg/m2,, LH/FSH ratio 2.8±0.9, aged 21-23 years were studied. Control consisted of 5 eumenorrhoeic, nonhirsute women, aged 22-32 with BMI 22.6±3.7 kg/m2, and LH/FSH ratio 1.3±0.6. A standard 3-hour OGTT was begun after an overnight fast. Blood samples were collected at 0, 60', 120', 180' of OGTT. Insulin, testosterone (T), androstenedione (A) and dehydroepiandrosterone sulfate (DHEAS) were measured by RIA and SHBG, FSH, LH by IRMA. The significant differences between the study and control groups were observed as follows: A0 - 1.9±0.1 vs 1.33&plusm;0.2; A120' - 1.52±0.1 vs 0.75±0.1 (ng/mL); SHBG120' - 46.9±22.9 vs 71.6±6.3; S±HBG180' - 46.9±22.9 vs 69.5±3.7 (nmol/l); insulin60' - 94.9±52.0 vs 37.2±15.5; insulin120' - 91.4±49.6 vs 38.8±10.9 (IU/mL); LH - 16.12±6.4 vs 8.0±2.0 (mIU/mL). A negative correlation was shown between insulin and SHBG values in the PCOS women during the glucose load. Fasting insulin levels correlated positively with fasting DHEAS levels in healthy women. Our data confirm the influence of insulin on serum SHBG and androgen levels. Thus, the treatment of hyperandrogenism in PCOS patients should include the reduction of hyperinsulinemia.

Keywords: androgen, Insulin Resistance

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

26 Feb 2024 : Clinical Research  

Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...

Med Sci Monit In Press; DOI: 10.12659/MSM.942509  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750