01 July 1996
Role of neutrophil collagenase in cervical remodelling
Tomasz Rochberger, Marek Gogacz, Krzysztof Postawski, Paweł Skorupski, Jerzy A. JakowickiMed Sci Monit 1996; 2(4): CR424-427 :: ID: 499909
Abstract
Human cervical remodelling during parturition is thought to depend principally on local collagenase activity originating mainly from polymorphonuclear leukocytes. The hypothesis to be tested was whether collagenase activity within granules of polymorphonuclear leukocytes is markedly increased at the time of delivery. Polymorphonuclear leukocytes collagenase activity in pregnant and non-pregnant women was measured by a method using [3H] labelled telopeptide free type I collagen. Collagenase activity in polymorphonuclear leukocytes immediately post-partum was higher than in non-pregnant patients. After delivery almost all the extracted collagenase was active when compared to that of late gestation. The number of leukocytes and the percentage of neutrophils were significantly higher than in non-pregnant patients. An increase in polymorphonuclear leukocyte collagenase activity at the time of parturition might be responsible for the proper timing of collagen breakdown within the uterine cervix.
Keywords: collagenase, polymorphonuclear leukocytes, cervical dilatati
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
05 Mar 2024 : Clinical Research
Role of Critical Shoulder Angle in Degenerative Type Rotator Cuff Tears: A Turkish Cohort StudyMed Sci Monit In Press; DOI: 10.12659/MSM.943703
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952