03 November 1997
Basal serum concentration of selected enterohormones and pancreatic hormones in patients with Turner's syndrome
Wojciech K. Cichy, Marian Krawczyński, Jerzy SmorawińskiMed Sci Monit 1997; 3(6): CR826-830 :: ID: 501789
Abstract
Background: Turner syndrome (Ts) is a natural model for the analysis of insufficient function of the ovaries on the operation of other organs, e. g. pancreas, intestine or stomach. Ts patients demonstrated a more frequent occurrence of impaired carbohydrate metabolism, and its pathogenesis has not been fully explained yet. Theoretical data imply that the change of entero-pancreatic axis activity may play a role in this phenomenon. The aim of the study was to explain the influence of selected enterohormones (EH) and pancreatic hormones (PH) on the condition of systemic dyshormonism as well as to define the role of these hormones in the maintenance of carbohydrate homeostasis (taking into consideration their influence upon potential diabetes occurrence) in Ts patients.
Results/Conclusions: 1. The changes in the profiles of basal serum concentrations of enterohormones (IG, GIP) and pancreatic hormones (IRI, CRP, PP) confirm their part in the regulation of impaired carbohydrate metabolism which occurs in patients without oestrogenic function of the gonads in the course of Turner syndrome. 2. The decreased incretin function of entero-pancreatic axis, preceding the occurrence of diabetes, may be responsible for the impairment of carbohydrate metabolism which develops with Ts patients' age.
Material/Methods:The study included 13 patients with Turner syndrome, with 45, X karyotype, aged 4-23. Radioimmunoassay (RIA) was applied in order to determine basal serum concentrations of selected PH (IRI, CRP, PP) and EH (IG and GP).
Keywords: Turner, glucose tolerance, entero-pancreatic axis, enterohormones
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
05 Mar 2024 : Clinical Research
Effects of Thermal Insulation on Recovery and Comfort of Patients Undergoing Holmium Laser LithotripsyMed Sci Monit In Press; DOI: 10.12659/MSM.942836
05 Mar 2024 : Clinical Research
Role of Critical Shoulder Angle in Degenerative Type Rotator Cuff Tears: A Turkish Cohort StudyMed Sci Monit In Press; DOI: 10.12659/MSM.943703
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952