30 April 1999
Kinins influence on energetic processes during the ischemia - reperfusion syndrome
Hanna Krauss, Jacek Kozlik, Paweł Chęciński, Przemysław Sosnowski, Kinga Mikrut, Łukasz DzieciuchowiczMed Sci Monit 1999; 5(3): BR410-414 :: ID: 504740
Abstract
Background: Tissue ischemia leads towards a significant depletion of cellular high-energy compounds. Kinins stabilize the pool of cellular high-energy compounds during ischemia and reperfusion. Their protective action mechanism remains partially understood. The purpose of this study was to determine the influence of kinins on the activity of selected Krebs cycle and pentose phosphate pathway enzymes as well as on levels of cellular high-energy compounds during ischemia and reperfusion.
Material/Methods: We used an experimental model of ischemia-reperfusion in the rats hind limb. Placebo, bradykinin, captopril or captopril with bradykinin receptor antagonists were administered intraperitoneally before reperfusion. We measured the levels of adenine nucleotides as well as isocitrate dehydrogenase (EC 1.1.1.42) and glucose-6-phosphate dehydrogenase activities (EC 1.1.1.49) in skeletal muscles during ischemia and the 1st, 3rd and 10th minute of reperfusion.
Results: Ischemia-reperfusion led to a significant reduction of adenyl nucleotide levels and enzymes activities. The administration of captopril and bradykinin produced a significant decrease of measured values. Bradykinin receptor antagonists suppressed the beneficial influence of captopril.
Conclusions: Kinins that activate Krebs cycle and pentose phosphate pathway enzymes exert a protective effect on the energetic balance in rat skeletal muscles, during ischemia and reperfusion.
Keywords: adenylate energy charde, Kinins, ischemia-reperfusion
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952