01 March 1999
Non-neoplastic lymphocyte subsets in patients with B-cell chronic lymphocytic leukemia (B-CLL)
Urszula Podstawka, Joanna Kopeć-Szlężak, Grażyna Pałynyczko, Ewa Mendek-Czajkowska, Lech KonopkaMed Sci Monit 1999; 5(2): CR239-245 :: ID: 505095
Abstract
Since the early 1980s we observed populations of T lymphocytes and NK cells of B-cell chronic lymphocytic leukemia (B-CLL)patients, reveal changes as compared with T and NK cells of healthy donors. The aim of this study was to determine relations between T-lymphocyte subpopulations and NK-cell subsets in patients with B-CLL in various stages of the disease.Peripheral blood cells of B-CLL patients had been analysed by means of flow cytometry and monoclonal antibodies. Lymphocyte surface markers had been evaluated by means of direct immunofluorescence. We evaluated the absolute number of each lymphocyte subset. Study results revealed that there was a significant increase in the number of T- and NK-cell populations that correlates with the progression of the disease. Following effective therapy of B-CLL Rai stage III/IV patients (blood lymphocyte count <30x109/l) there was a considerable decrease of T CD3+ and T CD8+ lymphocytes (to control values) and a significant decrease of T CD4+ and NK cells (below minimal control values). The number of T and NK cell subpopulations was not constant and this instability might have been the cause of immune response impairment observed in B-CLL patients. T lymphocytes and NK cells showed normal expression of an adhesion LFA-1 molecule.
Keywords: Rai stage, B-cell chronic lymphocytic leukemia, NK cells, T cell subpopulations
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952