Percutaneous injection of chemotherapeutic drugs in the guidance of magnetic resonance imaging for the treatment of cholangiocarcinoma
Zhi-Hua Liu, Peng Zhang, Yu-Kun Zhou, Huan-Long Qin
Med Sci Monit 2010; 16(12): HY31-33
The morbidity and mortality of cholangiocarcinoma have been rising yearly. However, conventional therapies still cannot achieve a satisfactory survival rate. Furthermore, there is an urgent need to discover new approaches to overcome chemotherapeutic drug resistance of cholangiocarcinoma. Considering the unique advantage of magnetic irradiation, we hypothesize that percutaneous injection of chemotherapeutic drugs in the guidance of nuclear magnetic resonance imaging may enhance the survival rate of cholangiocarcinoma without increasing undesired side effects.
Keywords: Drug Delivery Systems - methods, Cholangiocarcinoma - drug therapy, Bile Ducts, Extrahepatic, Bile Duct Neoplasms - drug therapy, Administration, Cutaneous, Humans, Magnetic Resonance Imaging - methods