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20 August 2016 : Review article  

Role of Osterix and MicroRNAs in Bone Formation and Tooth Development

Chuan WangE, Haiqing LiaoE, Zhengguo CaoA

DOI: 10.12659/MSM.896742

Med Sci Monit 2016; 22:2934-2942

Abstract

Osterix (Osx) is an osteoblast-specific transcription factor that is essential for bone formation. MicroRNAs (miRNAs) are ~22-nucleotide-long noncoding RNAs that play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression. They can also control osteoblast-mediated bone formation and osteoclast-related bone remodeling. The vital roles of Osx and miRNAs during bone formation have been well studied, but very few studies have discussed their co-functions and the relationships between them. In this review, we outline the significant functions of Osx and miRNAs on certain cell types during osteogenesis and illustrate their roles during tooth development. More importantly, we discuss the relationship between Osx and miRNAs, which we believe could lead to a new treatment for skeletal and periodontal diseases.

Keywords: Chondrocytes - metabolism, Osteoblasts - metabolism, Osteogenesis, Tooth - metabolism, Transcription Factors - metabolism

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Editorial

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750