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Role of Transient Receptor Potential Channels in Heart Transplantation: A Potential Novel Therapeutic Target for Cardiac Allograft Vasculopathy

Shuo Ma, Yue Jiang, Weiting Huang, Xintao Li, Shuzhuang Li

(Department of Physiology, Dalian Medical University, Dalian, Liaoning, China (mainland))

Med Sci Monit 2017; 23:2340-2347

DOI: 10.12659/MSM.901920

Published: 2017-05-18


ABSTRACT: Heart transplantation has evolved as the criterion standard therapy for end-stage heart failure, but its efficacy is limited by the development of cardiac allograft vasculopathy (CAV), a unique and rapidly progressive form of atherosclerosis in heart transplant recipients. Here, we briefly review the key processes in the development of CAV during heart transplantation and highlight the roles of transient receptor potential (TRP) channels in these processes during heart transplantation. Understanding the roles of TRP channels in contributing to the key procedures for the development of CAV during heart transplantation could provide basic scientific knowledge for the development of new preventive and therapeutic approaches to manage patients with CAV after heart transplantation.

Keywords: endothelial cells, Heart Transplantation, Muscle, Smooth, Vascular, Transient Receptor Potential Channels



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