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Etoposide added to weekly leucovorin (LV)//5-fluorouracil (5-FU) in LV/5-FU pre-treated patients with advanced colorectal cancer

Nicolas Tsavaris, Christos Kosmas, Kostas Gennatas, Maria Vadiaka, Platon Paliaros, Antonis Dimitrakopoulos, Theodoros Diamantis, Heraklis Tsipras, George Papastratis

Med Sci Monit 2002; 8(9): PI65-69

ID: 13494


Background: We evaluated the efficacy and safety of the weekly combination of etoposide, leucovorin (LV) and 5-fluorouracil (5-FU) when administered as second-line chemotherapy in patients with
relapsed/refractory advanced colorectal cancer (ACC), previously treated with weekly LV+5- FU.
Material/Methods: Etoposide was administered at 3 different dose levels (DL), in 3 groups of patients (total=60): DL-I – etoposide 80 mg/m2, 45 min i.v. infusion, DL-II – etoposide 120 mg/m2, and DL-III – etoposide 180 mg/m2. In all three levels etoposide was followed by LV 100 mg/m2 i.v., 1-hour infusion, and 5-FU 500 mg/m2 i.v. bolus. Treatment was administered until disease progression
or unacceptable toxicity.
Results: No patients responded at DL-I, while 2 patients at DL-II and 3 at DL-III had a partial response (PR) (P

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