12 March 2002
Leptin and estradiol as related to change in pubertal status and body weight.
Tami Irwin Sherman, Vicky L Funanage, Sandra G Hassink, Karen Oerter KleinMed Sci Monit 2002; 8(3): CR206-210 :: ID: 420890
Abstract
BACKGROUND: Previous studies have examined the relationship between leptin,body mass, and pubertal status. The present study directly compares the relationship of leptin and estradiolin 5 groups of girls with different combinations of pubertal status and weight. MATERIAL/METHODS: Westudied girls with idiopathic precocious puberty, age-matched non-obese prepubertal girls, age-matchedobese prepubertal girls, normal pubertal girls, and obese pubertal girls (n=12/group). RESULTS: Leptinlevels were significantly higher in obese pubertal girls (26.6+/-8.4 ng/mL) than in all others. Leptinlevels were significantly higher in obese prepubertal girls (20.7+/-10.9 ng/mL) (mean+/-SD) comparedto girls with precocious puberty (7.7±5.4 ng/mL, p<0.004), non-obese prepubertal girls (5.55±3.6 ng/mL, p<0.001), and normal pubertal girls (4.8±2.9 ng/mL, p<0.001). Leptin level did not correlate significantly with estradiol level. Leptin-SDS (standard deviation score), which corrects leptin level for gender, pubertal stage, and BMI, was significantly lower in the obese pubertal group than in the 3 non-obese groups.
Conclusions: These findings confirm previous studies that body mass, chronological age and pubertal stage are determinants of leptin level. However, these are not the only factors determining leptin
level as evidenced by persistent differences in leptin level between obese and non-obese pubertal girls even when correcting for pubertal stage and BMI. While the present study provides no new answers to the question of pubertal regulation, it provides a direct comparison of combinations of weight, pubertal stage, and leptin level, as background for future studies.
Keywords: Body Mass Index, Body Weight, Case-Control Studies, Child, Leptin, Obesity, Puberty, Puberty, Precocious
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
06 Mar 2024 : Clinical Research
Prevalence and Variation of Medical Comorbidities in Oral Surgery Patients: A Retrospective Study at Jazan ...Med Sci Monit In Press; DOI: 10.12659/MSM.943884
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952