01 September 1997
Gamma-sigma+ T cells and humoral response to hsp 65 and hsp 70 in subacute sclerosing panencephalitis
Urszula Fiszer, Grażyna Korczak-Kowalska, Wanda Sobczyk, Wanda SobczykMed Sci Monit 1997; 3(5): CR677-681 :: ID: 501590
Abstract
Several hypothesis have been put forward to explain the pathogenesis of subacute sclerosing panencephalitis (SSPE). However, the mechanisms leading to the lack of elemination of the virus still remain unclear. Due to the protection function of gd+ T cells in infections, the present investigation examined the percent of gd+ T cells out of all T cells and their characteristics in peripheral blood by flow cytometry. Heat shock proteins (hsps) play an important role in the response of neurons to different factors, therefore the existence of IgG and IgM antibodies against hsps in sera was examined by the ELISA in 14 patients with SSPE. These investigations were also carried out on a control group patients with other neurological diseases (OND). In SSPE patients the average percentage of gd+ T lymphocytes in the peripheral blood was higher (6.9±5.4%) in comparison with OND (1.9±1.9%). The percentage of subtype Vd1/gd+ T cells amounted to 18.5±17.0% in the SSPE patients and to 33.5±27.1% in OND. Active gd+ T cells (CD25+gd+T) were found in 2 of 12 patients with SSPE and in 5 of 14 patients with OND. No differences were found between mean ELISA ratios for IgG and IgM antibodies in the sera of SSPE and OND patients tested for antibodies against hsp 65 and hsp 70. The above data comes from patients with advanced disease treated with immunomodulatory drugs; they confirm a disturbances of cell response in patients with SSPE.
Keywords: gamma-sigma+ T cells, heat shock proteins, SSPE
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952