01 July 1998
Influence of propofol and ketamine in TIVA laparoscopic surgery on some hemodynamic and biochemical stress reaction parameters
Makgorzata Malinowska-Zaprzałka, Lidia MalinowskaMed Sci Monit 1998; 4(4): CR661-664 :: ID: 502308
Abstract
Most anesthetic and surgical procedures are connected with stress reactions. TIVA is a method most commonly used in laparoscopic cholecystectomy. There exists data suggesting the addition of ketamine to propofol in TIVA for particular surgical procedures. We tried to compare the effect of propofol and propofol with ketamine in TIVA laparoscopic procedures on some hemodynamic and biochemical stress reaction parameters. Our study group comprised 15 patients undergoing laparoscopic cholecystectomy under TIVA anesthesia with propofol (group I)or propofol with ketamine (group II). Heart rate, mean arterial pressure, peripheral hemoglobin saturation, end-tidal carbon dioxide concentration were monitored continuously, and cortisol and glucose blood levels were evaluated 10 and 40 min following intubation and 5 min after extubation, as well as the daily cortisol profile. Our study has demonstrated a lowering of blood pressure and a more pronounced rise in cortisol blood levels during TIVA in group I in comparison to group II, where ketamine was added. . We have demonstrated that ketamine added to propofol stabilizes hemodynamics, decreases the endocrine stress response and allows for the use of lower doses of propofol.
Keywords: anaesthesia, TIVA (total intravenous anesthesia), stress response, Propofol, Ketamine
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952