Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 January 1998

Domination hierarchy and gastric mucosa susceptibility to stress ulcerations in rats

Katarzyna Steplewska-Mazur, Zygmunt Steplewski, Grzegorz Mazur

Med Sci Monit 1998; 4(1): BR27-32 :: ID: 502817

Abstract

Stressors acting upon an individual cause stress reactions, aimed at mobilizing the organism, either to fight or to escape. They disturb, however, the functions of many systems and organs, including the alimentary tract. The most dangerous lesions of the alimentary tract caused by stress reactions are acute ulcerations of the gastric mucosa, the so-called stress ulcerations. One of the social characteristics of vertebrates is the hierarchy of domination and subordination. Differences in activation of particular components (axes) of the stress reaction have been noted between dominant and subordinate animals; the hypothalamic-adreno-medullary axis prevails in the case of dominant animals and the hypothalamic-adrenocortical one in the case of subordinates. The objective of the present study was to verify whether the position of an animal in the domination hierarchy affects the process of creating stress ulcerations of gastric mucosa, their size and histopathological features. Tests were performed on rats. Domination hierarchy was created for pairs of rats employing the model of competitive access to water. In order to create ulcerations of the gastric mucosa, animals were subjected to a water-immobilization stressor. Ulceration surface was measured employing a planimetric method. Stomach specimens were taken for histopathological analysis. Tissue specimens were stained with hematoxylin and eosin, following the PAS method and three color Masson's method and analyzed with the use of a light microscope. The data obtained indicates that dominant rats are much more resistant (by nearly 50%) to the effect of a water-immobilization stressor than subordinate rats and those which created no domination hierarchy. On the other hand, domination hierarchy does not influence the histopathological picture of the stress ulcerations produced. These results, along with a review of the literature suggests that the lower sensitivity of dominant rats to stress ulcerations of the gastric mucosa is associated with the prevailing hypothalamic-adrenomedullary axis and sympathetic activation in the stress reaction and with changes in the activity of the neurone systems. A final conclusion drawn on the basis of these results demonstrates that reaching a dominant position in domination hierarchy reduces the negative consequences of stress reactions, such as ulcerations of gastric mucosa.

Keywords: mucosa ulcerations

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750