01 November 1999
Influence of a water-soluble contrast medium (diatrizoate) on the activity of lipopolysaccharide- and interferon-gamma-stimulated peritoneal macrophages
Rafał KurzawaMed Sci Monit 1999; 5(6): BR1090-1094 :: ID: 503103
Abstract
Hysterosalpingography (HSG) seems to be of therapeutical importance. Several studies indicated increased pregnancy rates following HSG. Its therapeutical action is based on the reconstitution of the oviductal patency by means of the contrast medium, though the actual mechanism has never been established. Some reports suggested the effect of water-soluble contrast media (WSCM) on the activity of peritoneal macrophages, which in unexplained cases and endometriosis-associated infertility are claimed to be responsible for spermatozoal phagocytosis. Current experiments evaluated the influence of WSCM on the activity of stimulated macrophages. Mouse peritoneal macrophages were cultured with diatrizoate (WSCM), and spermatozoa. The production and release of tumor necrosis factor-α (TNFα), nitrates and prostaglandin F2α(PGF2α) were correlated with the activity of macrophages. Morphological studies were performed by means of a scanning electron microscope (SEM). Diatrizoate decreased the release of nitrite, but demonstrated no significant effect on PGF2α and TNFα. SEM demonstrated a decreased phagocytosing activity of macrophages cultured with diatrizoate. Current in vitro results demonstrated that contrast media used during HSG may inhibit peritoneal macrophages activity.
Keywords: sperm, Macrophages, Diatrizoate, Infertility, contrast medium, Nitric Oxide, Prostaglandins, tumor necrosis factor
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952