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Recurrent pericarditis as the initial manifestation of Familial Mediterranean fever

Kerem Okutur, Selcuk Seber, Erkan Oztekin, Cemal Bes, Fatih Borlu

Med Sci Monit 2008; 14(12): CS139-141

ID: 869467

Background: Familial Mediterranean fever is an autosomal recessive disease largely restricted to certain ethnic groups and presenting with recurrent febrile serositis attacks. Peritonitis, pleuritis, and synovitis are common manifestations; however, the pericardium is rarely affected.
Material and Method: In this case report, we describe a 25-year-old Turkish woman who presented with recurrent pericarditis of no obvious cause, which eventually responded to colchicine therapy. Using gene mutation analysis to detect the MEFV gene, the patient's condition was finally diagnosed as Familial Mediterranean fever.
Conclusions: Familial Mediterranean fever should be considered in patients with idiopathic recurrent pericarditis unresponsive to nonsteroidal anti-inflammatory medications and corticosteroids. Mutation analyses should be done.

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