06 November 2020 : Review article
Mitochondrial Fusion and Fission in Neuronal Death Induced by Cerebral Ischemia-Reperfusion and Its Clinical Application: A Mini-Review
DOI: 10.12659/MSM.928651
Med Sci Monit 2020; 26:e928651
Introduction to Cerebral Ischemia-Reperfusion
Mitochondrial Dynamics
Mitochondria and Ischemia-Reperfusion (I/R) Injury
Mitochondrial Fusion and Fission
Maintaining the Balance Between Mitochondrial Fusion and Fission
Dysfunctional Mitochondria in Neurons During the I/R Process
Unbalanced Mitochondrial Fusion/Fission Process Leads to Neuronal Apoptosis
Mitochondrial Autophagy Is Involved in Neuronal Death During I/R
Mitochondrial Dynamics and Other Forms of Neuronal Death Induced by I/R
Molecular Mechanisms Underlying Dysfunctional Mitochondrial Dynamics During the I/R Process
Experimental Interventions Targeting Dysfunctional Mitochondrial Dynamics Induced by I/R
Cerebral Ischemia-Reperfusion Drugs Targeting Mitochondrial Dysfunction
Drugs Targeting Mitochondrial ATP Channel
Drugs Targeting Mitochondrial Ca2
Conclusions
References