Figure 3 The circ_0005556 level was higher in GC and was correlated with a worse prognosis. (A) Circ_0005556 expression was tested by qRT-PCR in GC tissue and adjacent normal tissue specimens (*** P<0.001). (B) ROC analysis was carried out by using GC and normal tissues to explore the diagnostic value of circ_0005556. (C) Kaplan-Meier survival curve analysis showing the correlation between circ_0005556 level and prognosis in GC patients (** P<0.01). (D) Level of circ_0005556 was detected in the plasma samples from GC patients and healthy controls (*** P<0.001). (E) ROC analysis of circ_0005556 in the plasma samples of GC patients. (F) Correlation analysis between the GC tissue and plasma circ_0005556 levels (R2=0.0576, P=0.0089). (G) Circ_0005556 was examined in preoperative and postoperative GC patients (P=0.0215).