05 August 2020: Clinical Research
Exosomes Mediated Transfer of Circ_UBE2D2 Enhances the Resistance of Breast Cancer to Tamoxifen by Binding to MiR-200a-3p
Ke Hu BCD , Xianhao Liu BCD , Yi Li ABC , Qinyang Li DEF , Yijun Xu DEF , Wei Zeng DEF , Guocheng Zhong CDEF , Changhua Yu CDE*DOI: 10.12659/MSM.922253
Med Sci Monit 2020; 26:e922253
Figure 7 Exosomal circ_UBE2D2 accelerates tamoxifen resistance in vivo. (A) Tumor volume was assessed every 5 days. (B) Tumor weight was examined after 37 days. (C) The expression of circ_UBE2D2 and miR-200a-3p was detected by qRT-PCR in isolated tumor masses. (D) Protein expression of ERα, vimentin, and E-cad was evaluated tumor masses by western blot. * P<0.05, ** P<0.01. qRT-PCR – real-time polymerase chain reaction; ERα – estrogen receptor alpha; E-cad – E-cadherin.