Involvement of p53, p21, and Caspase-3 in Apoptosis of Coronary Artery Smooth Muscle Cells in a Kawasaki Vasculitis Mouse Model

Minghong Deng; Chunwang Lin; Xianglin Zeng; Jianping Zhang; Fang Wen; Ziguang Liu; Haiyan Wu; Xiaofeng Wu

doi:10.12659/MSM.922429

21 August 2020 : Animal Research

Involvement of p53, p21, and Caspase-3 in Apoptosis of Coronary Artery Smooth Muscle Cells in a Kawasaki Vasculitis Mouse Model

Minghong Deng^1ACE, Chunwang Lin^1AE*, Xianglin Zeng^1C, Jianping Zhang^1BD, Fang Wen^1C, Ziguang Liu^2B, Haiyan Wu^3B, Xiaofeng Wu^4B

DOI: 10.12659/MSM.922429

Med Sci Monit 2020; 26:e922429

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Figure 1 Pathological features of the coronary artery root in KD (A) and control (B) groups. The root of the coronary artery obtained from the KD vasculitis mice exhibited accumulation of foam cells and inflammatory cell infiltration, which were accompanied by dissolved and necrotic CASMCs, as arrows pointing to the positions. These pathological phenotypes were not present in the coronary artery of the control mice.

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Involvement of p53, p21, and Caspase-3 in Apoptosis of Coronary Artery Smooth Muscle Cells in a Kawasaki Vasculitis Mouse Model

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