Involvement of p53, p21, and Caspase-3 in Apoptosis of Coronary Artery Smooth Muscle Cells in a Kawasaki Vasculitis Mouse Model

Minghong Deng; Chunwang Lin; Xianglin Zeng; Jianping Zhang; Fang Wen; Ziguang Liu; Haiyan Wu; Xiaofeng Wu

doi:10.12659/MSM.922429

21 August 2020 : Animal Research

Involvement of p53, p21, and Caspase-3 in Apoptosis of Coronary Artery Smooth Muscle Cells in a Kawasaki Vasculitis Mouse Model

Minghong Deng^1ACE, Chunwang Lin^1AE*, Xianglin Zeng^1C, Jianping Zhang^1BD, Fang Wen^1C, Ziguang Liu^2B, Haiyan Wu^3B, Xiaofeng Wu^4B

DOI: 10.12659/MSM.922429

Med Sci Monit 2020; 26:e922429

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Figure 2 Comparison of p53 (A, C) and p21 (B, C) IRS values between the KD (n=12) and control groups (n=12). Cytoplasmic staining of p53 in CASMCs was moderate and strong in the mice of the KD group, whereas only mild or no staining was observed in mice of the control group (A). Cytoplasmic staining for p21 in CASMCs was moderate and strong in mice of the KD group, but mild or absent in mice of the control group (B). The IRS values for p53 and p21 were significantly different between the KD group and control group (C).

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Involvement of p53, p21, and Caspase-3 in Apoptosis of Coronary Artery Smooth Muscle Cells in a Kawasaki Vasculitis Mouse Model

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