21 August 2020: Animal Study
Involvement of p53, p21, and Caspase-3 in Apoptosis of Coronary Artery Smooth Muscle Cells in a Kawasaki Vasculitis Mouse Model
Minghong Deng 1ACE , Chunwang Lin 1AE* , Xianglin Zeng 1C , Jianping Zhang 1BD , Fang Wen 1C , Ziguang Liu 2B , Haiyan Wu 3B , Xiaofeng Wu 4BDOI: 10.12659/MSM.922429
Med Sci Monit 2020; 26:e922429
Figure 2 Comparison of p53 (A, C) and p21 (B, C) IRS values between the KD (n=12) and control groups (n=12). Cytoplasmic staining of p53 in CASMCs was moderate and strong in the mice of the KD group, whereas only mild or no staining was observed in mice of the control group (A). Cytoplasmic staining for p21 in CASMCs was moderate and strong in mice of the KD group, but mild or absent in mice of the control group (B). The IRS values for p53 and p21 were significantly different between the KD group and control group (C).