10 October 2020 : Clinical Research
miR-106a Targets Anoctamin 1 (ANO1) to Regulate Lipopolysaccharide (LPS)-Induced Inflammatory Response in Macrophages
Junfeng Heng1CDEF, Dingye Wu2BCD, Shiqi Lu1CDE*, Yiming Zhao2ABCDDOI: 10.12659/MSM.922479
Med Sci Monit 2020; 26:e922479
Figure 1 miR-106a expression is increased and anoctamin 1 (ANO1) expression is decreased in sepsis. (A, B) Messenger ribonucleic acid (mRNA) abundances of interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-α) were detected in the serum samples of sepsis patients or healthy volunteers by quantitative real-time polymerase chain reaction. (C, D) Secretion levels of IL-6 and TNF-α were detected in the serum samples of sepsis patients or healthy volunteers by enzyme-linked immunosorbent assay. (E, F) Abundances of miR-106a and ANO1 mRNA were examined in patients’ serum or that of healthy volunteers. * P<0.05.