28 June 2020 : Laboratory Research
Down-Regulation of the Mammalian Target of Rapamycin (mTOR) Pathway Mediates the Effects of the Paeonol-Platinum(II) Complex in Human Thyroid Carcinoma Cells and Mouse SW1736 Tumor Xenografts
Ling He1BCDE, Song Guo1BC, Taiyang Zhu1BCD, Chen Chen1ADEF*, Kun Xu1ABCDOI: 10.12659/MSM.922561
Med Sci Monit 2020; 26:e922561
Figure 3 The inhibitory effect of the paeonol-platinum(II) (PL-Pt[II]) complex on the cell cycle in SW1736 human anaplastic thyroid carcinoma cells and BHP7-13 human thyroid papillary carcinoma cells. (A–D) The DNA content in PL-Pt(II)-treated SW1736 cells and BHP7-13 cells, detected by flow cytometry using propidium iodide (PI) staining. (E) The proteins regulating the cell cycle were assessed using Western blot in SW1736 and BHP7-13 cells treated with 1.0 and 2.0 μM of PL-Pt(II). * P<0.05 and ** P<0.01 vs. untreated cells.