28 June 2020>: Lab/In Vitro Research
Down-Regulation of the Mammalian Target of Rapamycin (mTOR) Pathway Mediates the Effects of the Paeonol-Platinum(II) Complex in Human Thyroid Carcinoma Cells and Mouse SW1736 Tumor Xenografts
Ling He BCDE* , Song Guo BC* , Taiyang Zhu BCD* , Chen Chen ADEF* , Kun Xu ABC*DOI: 10.12659/MSM.922561
Med Sci Monit 2020; 26:e922561
Figure 4 The apoptotic effects of the paeonol-platinum(II) (PL-Pt[II]) complex on SW1736 human anaplastic thyroid carcinoma cells and BHP7-13 human thyroid papillary carcinoma cells. (A, B) The fraction of sub-G1 cells measured using flow cytometry at 48 h of treatment with 1.0 and 2.0 μM of PL-Pt(II). (C) Caspase-3 degradation in SW1736 and BHP7-13 cells treated with 1.0 and 2.0 μM of PL-Pt(II) assessed by Western blot. * P<0.05 and ** P<0.01 vs. untreated cells.