16 August 2020: Animal Study
Extract EGb761 Attenuates Bleomycin-Induced Experimental Pulmonary Fibrosis in Mice by Regulating the Balance of M1/M2 Macrophages and Nuclear Factor Kappa B (NF-κB)-Mediated Cellular Apoptosis
Ling Pan AD* , Yuehong Lu BCE , Zhanhua Li BCEF , Yuping Tan BF , Hongmei Yang BF , Ping Ruan CDF , Ruixiang Li BFDOI: 10.12659/MSM.922634
Med Sci Monit 2020; 26:e922634
Figure 1 EGb761 suppresses pulmonary inflammation induced by bleomycin (BLM) in mice. (A) Pulmonary inflammation of mice was evaluated by lung alveolitis score after treatment with BLM for 28 days. Lung tissues from normal mice (B), BLM-treated group (C), low-dose EGb761 group (D), mild-dose EGb761 group (E), and high-dose EGb761 group (F) were stained with hematoxylin and eosin; magnifications were 200×. All data are shown as mean±standard deviation (n=5). * P<0.05 vs. normal group; # P<0.05 vs. BLM group.