05 July 2020>: Clinical Research
Suppression of Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Potentiates Cell Apoptosis and Drug Sensitivity to Taxanes and Adriamycin in Breast Cancer
Jie Yu 1ABCDEF , Taobo Jin 2BCDEF , Tianya Zhang 2BCEF*DOI: 10.12659/MSM.922672
Med Sci Monit 2020; 26:e922672
Figure 4 MALAT1 silencing promotes Tax sensitivity of breast cancer cells. (A) The cell viability of MCF-7/Tax cells when exposed to gradient concentrations of Tax determined by CCK-8 assays. (B) Apoptosis rate of the MCF-7/Tax cells examined by flow cytometry analysis. Data are expressed as mean±SD. One-way ANOVA and Sidak’s multiple comparisons test were used to determine statistical significance, otherwise unpaired t-test was used, * P<0.05. Three independent experiments were performed. MALAT1 – metastasis-associated lung adenocarcinoma transcript 1; Tax – taxanes; CCK-8 – Cell Counting Kit-8; SD – standard deviations.