25 September 2020>: Lab/In Vitro Research
Long Non-Coding RNA Paternally Expressed Imprinted Gene 10 (PEG10) Elevates Diffuse Large B-Cell Lymphoma Progression by Regulating Kinesin Family Member 2A (KIF2A) via Targeting MiR-101-3p
Jin Zhao 1BCF* , Liping Su 1BCD* , Jianjun Jiang 2ACE*DOI: 10.12659/MSM.922810
Med Sci Monit 2020; 26:e922810
Figure 5 MiR-101-3p overexpression inhibits cell growth, metastasis and improves cell apoptosis in DLBCL. (A, B) MiR-101-3p level in DLBCL tissues and cells. (C) A negative relationship between PEG10 level and miR-101-3p level (R2=0.4241, P=0.0004). (D) The transfection efficiency of miR-101-3p in DLBCL cells. (E, F) Determination of cell growth and apoptosis in DLBCL cells. (G) Cell migration and invasion of DLBCL cells were measured by Transwell assays. (H) Western blot was used to detect the level of cyclinD1, Bcl-2, caspase-3, and Bax in SU-DHL-8 and OCI-LY-8 cells using western blot. * P<0.05. DLBCL – diffuse large B-cell lymphoma; PEG10 – paternally expressed imprinted gene 10.