Celastrol Inhibits Migration and Invasion of Triple-Negative Breast Cancer Cells by Suppressing Interleukin-6 via Downregulating Nuclear Factor-κB (NF-κB)

Fei Yan; Zihong Wu; Zihui Li; Li Liu

doi:10.12659/MSM.922814

13 September 2020 : Clinical Research

Celastrol Inhibits Migration and Invasion of Triple-Negative Breast Cancer Cells by Suppressing Interleukin-6 via Downregulating Nuclear Factor-κB (NF-κB)

Fei Yan^1BCDE, Zihong Wu^1BCD, Zihui Li^1ABCD, Li Liu^1BCDE*

DOI: 10.12659/MSM.922814

Med Sci Monit 2020; 26:e922814

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Figure 2 The influence of celastrol on migration and invasion of TNBC cells. (A, B) Cell migration was assessed in MDA-MB-231 and MDA-MB-468 cells after exposure to various doses of celastrol for 24 h by transwell assay. (C, D) Cell invasion was detected after treatment with various doses of celastrol for 24 h via transwell analysis. * P<0.05 vs. the non-treated group (0 μM).

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Celastrol Inhibits Migration and Invasion of Triple-Negative Breast Cancer Cells by Suppressing Interleukin-6 via Downregulating Nuclear Factor-κB (NF-κB)

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