13 September 2020: Clinical Research
Celastrol Inhibits Migration and Invasion of Triple-Negative Breast Cancer Cells by Suppressing Interleukin-6 via Downregulating Nuclear Factor-κB (NF-κB)
Fei Yan BCDE , Zihong Wu BCD , Zihui Li ABCD , Li Liu BCDE*DOI: 10.12659/MSM.922814
Med Sci Monit 2020; 26:e922814
Figure 3 The influence of IL-6 inhibition on migration and invasion of TNBC cells. The levels of IL-6 mRNA (A), protein (B) in cells and in cell medium (C) were examined in MDA-MB-231 and MDA-MB-468 cells transfected with sh-IL-6-1, sh-IL-6-2, or sh-NC by qRT-PCR, Western blot, or ELISA, respectively. (D, E) Cell migration and invasion were detected in MDA-MB-231 and MDA-MB-468 cells with transfection of sh-IL-6-1, sh-IL-6-2, or sh-NC by transwell assay. * P<0.05 vs. the negative control transfection group (sh-NC).