13 September 2020: Clinical Research
Celastrol Inhibits Migration and Invasion of Triple-Negative Breast Cancer Cells by Suppressing Interleukin-6 via Downregulating Nuclear Factor-κB (NF-κB)
Fei Yan BCDE , Zihong Wu BCD , Zihui Li ABCD , Li Liu BCDE*DOI: 10.12659/MSM.922814
Med Sci Monit 2020; 26:e922814
Figure 5 The effect of celastrol on NF-κB/IL-6 pathway. (A, B) The expressions of p-IKBα, IKBα, and p65 were measured in MDA-MB-231 and MDA-MB-468 cells after exposure to various doses of celastrol for 24 h by Western blot. (C, D) Luciferase activity of IL-6 reporter vector was analyzed in MDA-MB-231 and MDA-MB-468 cells after exposure to 1 μM celastrol for 24 h. * P<0.05 vs. the non-treated group (0 μM or control).