Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways

Jinbang Xu; Jingjing Dun; Juan Yang; Junxin Zhang; Qiuping Lin; Mingqing Huang; Feng Ji; Lishan Huang; Xiumi You; Ying Lin

doi:10.12659/MSM.923073

08 July 2020 : Animal Research

Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways

Jinbang Xu^1AEG*, Jingjing Dun^1CDE, Juan Yang^1DF, Junxin Zhang^1BF, Qiuping Lin^1B, Mingqing Huang^2B, Feng Ji^3B, Lishan Huang^3B, Xiumi You^1B, Ying Lin^3ABEG

DOI: 10.12659/MSM.923073

Med Sci Monit 2020; 26:e923073

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Figure 3 Ovarian morphology in Letrozole+HFD, Letrozole, HFD and control groups of rats. (A) Ovary from a Letrozole+HFD rat. (B) Ovary from a Letrozole rat. (C) Ovary from an HFD rat. (D) Ovary from a control rat. 3a & 3b – atretic follicles; 3c &3 d – graafian (tertiary) follicles.

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Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways

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