08 July 2020>: Animal Study
Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways
Jinbang Xu 1AEG** , Jingjing Dun 1CDE* , Juan Yang 1DF , Junxin Zhang 1BF , Qiuping Lin 1B , Mingqing Huang 2B , Feng Ji 3B , Lishan Huang 3B , Xiumi You 1B , Ying Lin 3ABEG*DOI: 10.12659/MSM.923073
Med Sci Monit 2020; 26:e923073
Figure 5 Blood glucose levels and AUC of glucose and insulin tolerance tests in Letrozole+HFD, Letrozole, HFD, and control groups of rats were measured with a Bayer Contour Glucometer. (A) Blood glucose during glucose tolerance tests. (B) AUC of glucose tolerance tests. (C) Blood glucose during insulin tolerance tests. (D) AUC of insulin tolerance tests. Data are presented as mean±SEM of 6 rats and analyzed by one-way ANOVA with Dunnett’s post hoc test. * P 0.05, ** P 0.01 compared with control group. # P 0.05, ## P 0.01 compared with Letrozole group.