08 July 2020 : Animal Research
Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways
Jinbang Xu1AEG*, Jingjing Dun1CDE, Juan Yang1DF, Junxin Zhang1BF, Qiuping Lin1B, Mingqing Huang2B, Feng Ji3B, Lishan Huang3B, Xiumi You1B, Ying Lin3ABEGDOI: 10.12659/MSM.923073
Med Sci Monit 2020; 26:e923073
Figure 6 Index of insulin resistance in Letrozole+HFD, Letrozole, HFD, and control groups of rats. Fasting blood glucose (FPG) was measured by an automated glucose oxidation method. Fasting insulin (FINS) levels were determined by RIA, and the homeostasis model assessment of insulin resistance (HOMA-IR) was evaluated by the homeostasis model assessment and calculated by the following formula: HOMA-IR=FINS×FPG/22.5. Data are presented as mean±SEM of 6 rats and analyzed by one-way ANOVA with Dunnett’s post hoc test. * P 0.05 compared with the control group. NS – not significant.