08 July 2020>: Animal Study
Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways
Jinbang Xu 1AEG** , Jingjing Dun 1CDE* , Juan Yang 1DF , Junxin Zhang 1BF , Qiuping Lin 1B , Mingqing Huang 2B , Feng Ji 3B , Lishan Huang 3B , Xiumi You 1B , Ying Lin 3ABEG*DOI: 10.12659/MSM.923073
Med Sci Monit 2020; 26:e923073
Figure 6 Index of insulin resistance in Letrozole+HFD, Letrozole, HFD, and control groups of rats. Fasting blood glucose (FPG) was measured by an automated glucose oxidation method. Fasting insulin (FINS) levels were determined by RIA, and the homeostasis model assessment of insulin resistance (HOMA-IR) was evaluated by the homeostasis model assessment and calculated by the following formula: HOMA-IR=FINS×FPG/22.5. Data are presented as mean±SEM of 6 rats and analyzed by one-way ANOVA with Dunnett’s post hoc test. * P 0.05 compared with the control group. NS – not significant.