08 July 2020 : Animal Research
Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways
Jinbang Xu1AEG*, Jingjing Dun1CDE, Juan Yang1DF, Junxin Zhang1BF, Qiuping Lin1B, Mingqing Huang2B, Feng Ji3B, Lishan Huang3B, Xiumi You1B, Ying Lin3ABEGDOI: 10.12659/MSM.923073
Med Sci Monit 2020; 26:e923073
Figure 7 Lipid profiles in Letrozole+HFD, Letrozole, HFD, and control groups of rats. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were measured by enzymatic colorimetric test technique. (A) Total cholesterol. (B) High-density lipoprotein cholesterol. (C) Low-density lipoprotein cholesterol. (D) TC/HDL-C ratio. Data are presented as mean±SEM of 6 rats and analyzed by one-way ANOVA with Dunnett’s post hoc test. * P 0.05, ** P 0.01, *** P 0.001 compared with control group. # P 0.05, ## P 0.01 compared with Letrozole group. NS – not significant.