13 July 2020 : Clinical Research
Long-Chain Non-Coding RNA Metastasis-Related Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes the Proliferation and Migration of Human Pulmonary Artery Smooth Muscle Cells (hPASMCs) by Regulating the MicroRNA-503 (miR-503)/Toll-Like Receptor 4 (TLR4) Signal Axis
Meng He1ABCDEF, Juxin Shen1ABCDF, Chunyi Zhang1ABCD, Yefeng Chen1BCDF, Weisi Wang2BCD, Kelong Tao3EG*DOI: 10.12659/MSM.923123
Med Sci Monit 2020; 26:e923123
Figure 1 Long-chain non-coding RNA metastasis-related lung adenocarcinoma transcript 1 (lncRNA MALAT1) is highly expressed in the plasma and hypoxic human pulmonary artery smooth muscle cells (hPASMCs) of patients with PAH. (A) Quantitative reverse transcription-PCR (qRT-PCR) detection of plasma lncRNA MALAT1 levels. (B) Receiver operating curve (ROC) for the diagnosis of PAH based on plasma lncRNA MALAT1 level. (C) Comparison of lncRNA MALAT1 levels in hypoxic and non-hypoxic hPASMC cells by RT-qPCR