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13 July 2020: Clinical Research

Long-Chain Non-Coding RNA Metastasis-Related Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes the Proliferation and Migration of Human Pulmonary Artery Smooth Muscle Cells (hPASMCs) by Regulating the MicroRNA-503 (miR-503)/Toll-Like Receptor 4 (TLR4) Signal Axis

Meng He 1ABCDEF , Juxin Shen 1ABCDF , Chunyi Zhang 1ABCD , Yefeng Chen 1BCDF , Weisi Wang 2BCD , Kelong Tao 3EG*

DOI: 10.12659/MSM.923123

Med Sci Monit 2020; 26:e923123

Figure 5 Long-chain non-coding RNA metastasis-related lung adenocarcinoma transcript 1 (lncRNA MALAT1) can directly target microRNA-503 (miR-503) as a competing endogenous RNAs (ceRNA). (A) Prediction of the binding site of lncRNA MALAT1 and miR-503. (B) Double luciferase reporter gene test results. * p<0.05, compared with the no template control (NC) group. (C) Toll like receptor-4 (TLR-4) mRNA expression in peripheral blood mononuclear cells (PBMCs) of PAH patients and healthy controls. (D) TLR4 protein expression in PBMCs of PAH patients and healthy controls.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750