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13 July 2020: Clinical Research

Long-Chain Non-Coding RNA Metastasis-Related Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes the Proliferation and Migration of Human Pulmonary Artery Smooth Muscle Cells (hPASMCs) by Regulating the MicroRNA-503 (miR-503)/Toll-Like Receptor 4 (TLR4) Signal Axis

Meng He 1ABCDEF , Juxin Shen 1ABCDF , Chunyi Zhang 1ABCD , Yefeng Chen 1BCDF , Weisi Wang 2BCD , Kelong Tao 3EG*

DOI: 10.12659/MSM.923123

Med Sci Monit 2020; 26:e923123

Figure 7 Long non-coding RNA metastasis-related lung adenocarcinoma transcript 1 (lncRNA MALAT1) regulates the proliferation of hPASMCs through microRNA-503 (miR-503). (A) Number of clones of hPASMCs after transfection with pcDNA-MALAT1, miR-503 mimic, pcDNA-MALAT1+miR-503 mimic, or no template control (NC). (B) Number of clones of hPASMCs after transfection with miR-503 inhibitor, sh-MALAT1, sh-MALAT1+miR-503 inhibitor, or NC. (C, D) Cell counting kit assays showing the proliferation of hPASMCs (C) after transfection with miR-503 inhibitor, sh-MALAT1, sh-MALAT1+miR-503 inhibitor, or NC, and (D) after transfection with pcDNA-MALAT1, miR-503 mimic, pcDNA-MALAT1+miR-503 mimic, or NC.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750