13 July 2020>: Clinical Research
Long-Chain Non-Coding RNA Metastasis-Related Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes the Proliferation and Migration of Human Pulmonary Artery Smooth Muscle Cells (hPASMCs) by Regulating the MicroRNA-503 (miR-503)/Toll-Like Receptor 4 (TLR4) Signal Axis
Meng He 1ABCDEF , Juxin Shen 1ABCDF , Chunyi Zhang 1ABCD , Yefeng Chen 1BCDF , Weisi Wang 2BCD , Kelong Tao 3EG*DOI: 10.12659/MSM.923123
Med Sci Monit 2020; 26:e923123
Figure 8 Long non-coding RNA metastasis-related lung adenocarcinoma transcript 1 (lncRNA MALAT1) regulates the migration and apoptosis of hPASMCs through microRNA-503 (miR-503). (A, B) Wound healing assays showing the migration of hPASMCs (A) after transfection with sh-MALAT1, miR-503 inhibitor sh-MALAT1+miR-503 inhibitor, or no template control (NC), and (B) after transfection with pcDNA-MALAT1, miR-503 mimic, pcDNA-MALAT1+miR-503 mimic, or NC. (C, D) Flow cytometry, showing the apoptosis of hPASMCs after (C) transfection with pcDNA-MALAT1, miR-503 mimic, pcDNA-MALAT1+miR-503 mimic, or NC, and (D) after transfection with, sh-MALAT1, miR-503 inhibitor, sh-MALAT1+miR-503 inhibitor, or NC.