18 June 2020 : Animal Research
Puerarin Inhibits Endothelium-Dependent Contractions in Mouse Carotid Arteries
Mei Chen1ABCDEF, Li Xiang2BF, Guangliang Wu2FG, Yingdi Liao3EF, Yefeng Cai12AFG*DOI: 10.12659/MSM.923163
Med Sci Monit 2020; 26:e923163
Figure 1 Puerarin inhibited endothelium-dependent contractions (EDCs) in mouse carotid artery. (A) The chemical structure of puerarin. (B, C) Concentration-dependent inhibitory effects of puerarin (10 μmol/L, n=5; 30 μmol/L, 50 μmol/L, n=6) on EDC compared to control (n=5). (D) The inhibitory effect of S18886 (30 nmol/L, n=4) but not puerarin (50 μmol/L, n=6) on U46619-induced contraction compared to control (n=5). The results are means±standard error of the mean (SEM). * P<0.05 vs. control.