Figure 3 Cyclooxygenase-2 (COX-2) not COX-1 mediated endothelium-dependent contractions (EDCs) in mouse carotid artery. (A) Original recordings showing the effect of COX-1 and COX-2 inhibitors on EDCs. (B) Lack of effect of the selective COX-1 inhibitor VAS (1 to 100 μmol/L, n=4) on acetylcholine (ACh)-induced contractions compared with control (n=7). (C) Concentration-dependent inhibitory effect of celecoxib (0.1 to 1 μmol/L, n=7) on EDCs compared with control (n=6). (D) Concentration-dependent inhibitory effect of Dup-697 (0.1 to 1 μmol/L, n=6) on ACh-induced contractions compared with control (n=6). The results are means±standard error of the mean (SEM). * P<0.05 versus control.