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29 August 2020: Animal Study

Mesenchymal Stem Cells Decrease M1/M2 Ratio and Alleviate Inflammation to Improve Limb Ischemia in Mice

Ye Song 1ABCEF , Tian-Jie Zhang 2BCF , Yuan Li 3BCF , Yuan Gao 4ACD*

DOI: 10.12659/MSM.923287

Med Sci Monit 2020; 26:e923287

Figure 3 Transplanted PMSCs modulated macrophage differentiation toward an M2-like macrophage phenotype in ischemic tissue. (A) Representative images of flow cytometry. (B) Quantification of macrophage phenotypes. The number of M2-like macrophages increased dramatically in the PMSCs group at day 1, 3, and 7, respectively. Moreover, the M1/M2 ratio was reduced in the PMSCs group at day 1, 3, 7, and 14 after the procedure, respectively. # P<0.05 for PMSCs group versus PBS group. Data are represented as mean±SEM.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750