29 August 2020>: Animal Study
Mesenchymal Stem Cells Decrease M1/M2 Ratio and Alleviate Inflammation to Improve Limb Ischemia in Mice
Ye Song 1ABCEF , Tian-Jie Zhang 2BCF , Yuan Li 3BCF , Yuan Gao 4ACD*DOI: 10.12659/MSM.923287
Med Sci Monit 2020; 26:e923287
Figure 3 Transplanted PMSCs modulated macrophage differentiation toward an M2-like macrophage phenotype in ischemic tissue. (A) Representative images of flow cytometry. (B) Quantification of macrophage phenotypes. The number of M2-like macrophages increased dramatically in the PMSCs group at day 1, 3, and 7, respectively. Moreover, the M1/M2 ratio was reduced in the PMSCs group at day 1, 3, 7, and 14 after the procedure, respectively. # P<0.05 for PMSCs group versus PBS group. Data are represented as mean±SEM.