29 August 2020>: Animal Study
Mesenchymal Stem Cells Decrease M1/M2 Ratio and Alleviate Inflammation to Improve Limb Ischemia in Mice
Ye Song 1ABCEF , Tian-Jie Zhang 2BCF , Yuan Li 3BCF , Yuan Gao 4ACD*DOI: 10.12659/MSM.923287
Med Sci Monit 2020; 26:e923287
Figure 5 Transplanted PMSCs promoted the neovascularization in ischemic limbs. (A) Representative images of immunofluorescent staining for CD31 (×200). The red arrows indicate the blood vessel. (B) Quantification of CD31-positive vessel density from the immunofluorescent staining images. The density of CD31-positive vessels was significantly elevated in the PMSCs group at day 7 and 14 after the procedure. (C) Representative images of immunofluorescent staining for α-SMA (×200). The yellow arrows indicate the blood vessel. (D) Quantification of α-SMA-positive vessel density from the immunofluorescent staining images. The density of α-SMA-positive vessels was significantly elevated in the PMSCs group at day 7 and 14 after the procedure. # P<0.05 for PMSCs group versus PBS group. Data are represented as mean±SEM.