Network Pharmacology Study of the Hepatoprotective Effects of Quercetin-Containing Traditional Chinese Medicine, Anoectochilus roxburghii, and Validation of Quercetin as an Anti-Liver Injury Agent in a Mouse Model of Liver Injury

Wei Lin; Yuhan Wu; Jingjing Wang; Han Lin; Xiuming Xu; Guanrong He; Bizhu He; Xiaokai Ma

doi:10.12659/MSM.923533

16 December 2020 : Animal Research

Network Pharmacology Study of the Hepatoprotective Effects of Quercetin-Containing Traditional Chinese Medicine, Anoectochilus roxburghii, and Validation of Quercetin as an Anti-Liver Injury Agent in a Mouse Model of Liver Injury

Wei Lin^12ABCDEF, Yuhan Wu^3ABCDF, Jingjing Wang^3BCDF, Han Lin^2BCDF, Xiuming Xu^1ADF, Guanrong He^4A, Bizhu He^23AG*, Xiaokai Ma^12AF

DOI: 10.12659/MSM.923533

Med Sci Monit 2020; 26:e923533

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Figure 3 Processing of the topological analysis of the protein–protein interaction (PPI) network. The blue nodes represent the original input targets, and the red nodes represent the selected targets after topological analysis. The width of edges represents combined score. (A) original input targets in the PPI network; (B) sub-filtered targets in the PPI network based on the degree centrality (DC), betweenness centrality (BC), and closeness centrality (CC) values; (C) hub targets in the PPI network.

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Network Pharmacology Study of the Hepatoprotective Effects of Quercetin-Containing Traditional Chinese Medicine, Anoectochilus roxburghii, and Validation of Quercetin as an Anti-Liver Injury Agent in a Mouse Model of Liver Injury

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