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29 June 2020: Lab/In Vitro Research

WNT974 Inhibits Proliferation, Induces Apoptosis, and Enhances Chemosensitivity to Doxorubicin in Lymphoma Cells by Inhibiting Wnt/β-Catenin Signaling

Senmin Chen A , Xiuli Yuan B , Huanli Xu C , Meng Yi E , Sixi Liu G* , Feiqiu Wen F*

DOI: 10.12659/MSM.923799

Med Sci Monit 2020; 26:e923799

Figure 4 Effect of WNT974 on expression of apoptosis-related proteins in HUT-78 cells. (A) Representative immunoblot analysis for apoptosis-related proteins in HUT-78 cells before and after WNT974 treatment. (B–E) Relative protein expression of (B) anti-apoptosis protein Bcl-2, pro-apoptosis proteins (C) Bax, (D) cleaved- and pro-caspase 3 and (E) cleaved- and pro-caspase 9 after normalization to GAPDH (n=3). ** P<0.01 and *** P<0.001 vs. control.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750